منابع مشابه
Infection, Inflammation and Healing in Zebrafish: Intestinal Inflammation
Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, contribute to significant morbidity and mortality globally. Despite an increase in incidence, IBD onset is still poorly understood. Mouse models of IBD recapitulate several aspects of human disease, but limited accessibility for live imaging and the lack of forward genetics highlight the need for new model ...
متن کاملEpigenetic control of intestinal barrier function and inflammation in zebrafish.
The intestinal epithelium forms a barrier protecting the organism from microbes and other proinflammatory stimuli. The integrity of this barrier and the proper response to infection requires precise regulation of powerful immune homing signals such as tumor necrosis factor (TNF). Dysregulation of TNF leads to inflammatory bowel diseases (IBD), but the mechanism controlling the expression of thi...
متن کاملNeuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation.
Because neurotensin (NT) and its high-affinity receptor (NTR1) modulate immune responses, chloride secretion, and epithelial cell proliferation, we sought to investigate their role in the repair process that follows the development of mucosal injuries during a persistent inflammation. Colonic NT and NTR1, mRNA, and protein significantly increased only after dextran sodium sulfate (DSS)-induced ...
متن کاملEffect of microalgae on intestinal inflammation triggered by soybean meal and bacterial infection in zebrafish
Soybean meal has been used in many commercial diets for farm fish; despite this component inducing intestinal inflammation. On the other hand, microalgae have increasingly been used as dietary supplements in fish feed. Nevertheless, the vast quantity of microalgae species means that many remain under- or unstudied, thus limiting wide scale commercial application. In this work, we evaluated the ...
متن کاملSoybean Meal Induces Intestinal Inflammation in Zebrafish Larvae
The necessary replacement of fish meal with other protein source in diets of commercially important fish has prompted the study of the effect of the inclusion of different vegetable proteins sources on growth performance and on the gastro-intestinal tract. Currently, soybean meal is the primary protein source as a fish meal replacement because of its low price and high availability. Likewise, i...
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ژورنال
عنوان ژورنال: Current Pathobiology Reports
سال: 2015
ISSN: 2167-485X
DOI: 10.1007/s40139-015-0079-x